What Are Exosomes and What Does the Current Evidence Say?

In the world of aesthetic medicine, certain trends rise quickly, often carried by celebrity endorsements, viral posts, or promises of skin-transforming results. Few recent innovations have generated more buzz (or confusion) than exosomes.

But what are exosomes, really? What does the science say about their role in regenerative aesthetics? And are they safe, effective, and evidence-backed, or simply the latest in a long line of overhyped ingredients?

At Allure Aesthetics, our approach to innovation is evidence-first. In this article, we break down the current research, clarify what exosome products are (and aren’t), and offer guidance for anyone curious about this promising but still-evolving field.

What Are Exosomes?

Exosomes are nano-sized extracellular vesicles (typically 30–150 nm) released by nearly all cell types in the body. They act as biological messengers, carrying proteins, lipids, DNA, and RNA between cells to regulate inflammation, immune responses, wound healing, and more.

Think of them as small packages that allow cells to communicate, coordinate, and repair.

They are found naturally in blood, saliva, urine, and even breast milk, and their cargo reflects the health and function of their source cells.

Why Are Exosomes Being Explored in Aesthetics?

In aesthetic medicine, exosomes are being explored for their regenerative properties. When applied topically, with microneedling, or injected into the skin or scalp, they may help:

  • Stimulate collagen and elastin production
  • Reduce inflammation post-procedure
  • Accelerate wound healing
  • Improve skin texture, tone, and hydration
  • Support hair follicle growth in thinning hair

These effects stem from exosomes’ ability to deliver bioactive molecules (like growth factors, microRNAs, and cytokines) directly into cells. Their small size allows for deeper penetration and efficient cellular signaling.

What Types of Exosome Products Are Being Used?

Currently, most exosome products used in aesthetics fall into three broad categories:

1. Stem Cell-Derived Exosomes

Derived from mesenchymal or adipose-derived stem cells (adult stem cells found in fat, bone marrow, or umbilical tissue that support healing and collagen production). These are the most commonly used in regenerative therapies.

2. Platelet-Derived Exosomes

Often found within or isolated from PRP (platelet-rich plasma). While promising, direct evidence for isolated use remains limited.

3. Plant-Based Exosomes

Sourced from botanicals like aloe or rice. These are used in skincare, but clinical data on human efficacy is sparse.

Most exosome products are applied topically (often after microneedling or laser), but others are exploring injectable use for deeper delivery.

Type Evidence in Aesthetics Common Uses Limitations
Stem Cell-Derived Strongest evidence (especially MSCs) Skin rejuvenation, hair restoration, wound healing High variability
Platelet-Derived Moderate (mostly extrapolated from PRP data) Tissue repair, anti-aging, post-laser Few direct studies on isolated exosomes
Plant-Based Preliminary (mostly preclinical) Scar treatment, pigmentation support Sparse clinical data in human subjects

 

*Important Note: As of this writing, no exosome product is FDA-approved for treating medical conditions, even in aesthetic use. All current uses are off-label or marketed as cosmetic.

What Are Some of the Leading Exosome Products in Aesthetics?

Several brands have emerged as leaders in the aesthetic space. While product popularity varies by region and provider philosophy, the following are among the most widely used:

Product Name Origin Common Use Cases Regulatory Status Notes
BENEV Exosome Regenerative Complex Adipose-derived MSCs Skin rejuvenation, post-laser recovery Cosmetic use only Widely used post-microneedling
ExoCoBio (ASCE+) Umbilical cord MSCs Skin texture, tone, anti-aging Cosmetic use only Popular Korean brand with global reach
XoGlo Bone marrow-derived MSCs Anti-aging, regenerative medicine Cosmetic use only Marketed for regenerative and anti-aging protocols
ExoIE Purified stem cell vesicles Skin repair, barrier support Cosmetic use only Formulated for clinical-grade skincare use
Plated Platelet-derived exosomes Daily skin repair, maintenance Cosmetic use only High-end luxury retail skincare brand

 

*All listed products are marketed as cosmetics. None are FDA-approved for therapeutic or aesthetic medical use.

While these products vary in origin and composition, most are intended for:

  • Use post-procedure (e.g., laser, microneedling)
  • Home skincare regimens
  • Hair restoration protocols

Despite promising short-term outcomes in early clinical and case studies, all share the same caveats:

  • Lack of long-term safety data
  • Absence of regulatory approval
  • Significant variability in manufacturing protocols

Is There Clinical Evidence for Exosome Use in Aesthetics?

Yes and no. While early studies are promising, the field remains in its infancy. Here’s what we know so far:

Supportive Early Evidence

Several small clinical trials and preclinical studies have reported:

  • Improved healing and reduced downtime after microneedling and laser procedures
  • Enhanced skin texture, tone, and elasticity
  • Increased hair density and follicle activity in early-phase hair restoration protocols
  • Reduced pigmentation and post-inflammatory erythema

Studies tend to focus on stem cell-derived exosomes, especially from human umbilical or adipose tissue. Results suggest enhanced extracellular matrix remodeling (supporting skin structure and firmness), angiogenesis (formation of new blood vessels for better circulation and healing), and anti-inflammatory effects.

Major Gaps Remain

Despite early excitement, we must be clear:

  • Most studies are small, short-term, and lack control groups
  • There is no standardized dosing or delivery protocol
  • Many products vary dramatically in source material, purification, and quality
  • Long-term safety data is not yet available

How Does Using Exosomes Compare to PRP or Microneedling Alone?

Some clinics now offer exosome add-ons to procedures like PRP or microneedling, claiming superior results. Is that supported?

  • PRP does naturally contain exosomes released by platelets and is proven effective, but also includes a broader mix of cytokines and growth factors than exosomes.
  • Exosome products may be more targeted and consistent in molecular cargo, but lack the full spectrum found in PRP.
  • Early split-face studies suggest faster healing and greater glow when exosomes are applied after microneedling compared to microneedling alone.

Bottom line: Exosomes may complement, not replace, established regenerative treatments like PRP or PRF.

Woman receiving microneedling treatment for skin rejuvenation, a common method for exosome delivery in medical aesthetics.
Microneedling is often used to enhance the delivery of exosomes, helping them penetrate deeper into the skin to support regeneration, repair, and collagen production.

What Type of Exosomes Are Best With Microneedling?

Based on current evidence, mesenchymal stem cell-derived exosomes (MSC-Exo) appear to be the most appropriate choice when used in conjunction with microneedling. These exosomes have demonstrated meaningful regenerative effects, including:

  • Improved skin texture and elasticity
  • Enhanced hydration and pigmentation balance
  • Accelerated wound healing

Mechanistic studies show that MSC-Exo modulate key cellular pathways involved in collagen production, cell proliferation, and anti-inflammatory activity, making them well suited for post-procedure recovery and skin rejuvenation.

Other exosome types studied in conjunction with microneedling include:

  • Lactobacillus-derived exosomes (LDE): Appears to be effective for acne, PIH, and atrophic scars in early observational data.
  • Plant-derived exosomes (e.g., rose stem cell): May support scar remodeling with good tolerability, though clinical experience is limited.

Direct head-to-head studies are lacking. However, the consensus in available literature supports MSC-derived exosomes as the most broadly applicable and well-studied add-on for microneedling in aesthetics.

Are There Any Risks or Side Effects?

Short-term safety appears favorable. Reported side effects are generally mild and localized:

  • Redness
  • Swelling
  • Tenderness
  • Pruritus (itching) or irritation (especially with microneedling)

However, potential risks include:

  • Immunogenicity (risk of triggering an unwanted immune response) if exosomes are poorly characterized
  • Infection transmission if products aren’t properly sterilized
  • Oncogenic signaling  – a theoretical risk of triggering abnormal cell growth if exosomes come from improperly screened sources.

The lack of standardized manufacturing or regulation makes it critical to choose providers and products carefully.

Our Position at Allure Aesthetics

At Allure, we’re always exploring the most promising advances in aesthetic medicine—exosomes included. While this field is still evolving, the early evidence around topical exosome use is exciting, especially in conjunction with procedures like microneedling.

We’re actively reviewing the latest research, evaluating product options, and considering how this could complement our approach to long-term, relationship-based care.

If and when we find an exosome product that meets our standards for safety, transparency, and clinical benefit, we’ll be proud to offer it. As always, any new service we introduce will reflect the same level of integrity, education, and individualized care you’ve come to expect from us.

Frequently Asked Questions (FAQ)

Are exosome facials FDA-approved?

No. As of 2025, no topical or injectable exosome products are FDA-approved to treat any specific medical condition or dermatologic disease. Current aesthetic use is limited to general cosmetic applications, such as supporting skin quality and post-procedure recovery.

Do exosomes replace PRP?

Not necessarily. They may offer more targeted effects but lack PRP’s full spectrum of growth factors. They may work well together, or be used for different purposes.

Are exosome treatments safe?

Short-term studies suggest minimal risks, but long-term safety data are lacking. Source and manufacturing matter greatly.

Can I use exosome serums at home?

Some skincare brands include exosome-like ingredients, but efficacy varies. These are not the same as clinical-grade products.

Final Thoughts

Exosomes hold incredible promise for skin and regenerative medicine—but they are not a miracle shortcut. They are a tool, not a magic fix. At Allure Aesthetics, we believe your care should be thoughtful, individualized, and rooted in trust.

If you have questions about regenerative treatments or want guidance on what’s right for your skin goals, we’re here to help. Feel free to email us at info@allureaestheticsllc.com or call or text us at 610 393-1253. If you’d like to schedule an appointment to discuss all your goals and options, please visit our booking page.

Evidence Matters.

At Allure, we believe informed decisions start with credible information. Below, you’ll find a selection of references that helped guide the content in this article. If you’re interested in a deeper dive into the science behind exosomes, we welcome you to explore them.

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